Owners of 2015-2021 Chevy Colorado vehicles may state that the remote functions are inoperative or delayed after the first button is depressed (driver door unlocks and the second press does not unlock the passenger door, or the door lock button is pressed and the doors lock but then the RVS does not respond). 

It is suggested to inspect if aftermarket LED dome lamps have been installed. These have been found to emit a frequency that blocks the remote functions when the lamps illuminate. You may need to replace the LED lights with factory lights to restore proper remote functions.