Is there any benefit to running 22.5 versus 24.5 low pro tires on tractors or trailers?

Q: Is there any benefit to running 22.5 vs 24.5 low pro tires on tractors or trailers? I've always wondered why someone would choose one over the other.

A: From the fuel economy and tread wear standpoints, I don't think you would find a measurable advantage to either size (all other things being equal).

I would go with the 22.5 tire just because it is more common and more readily available in the open market.